DIPG: Diffuse Intrinsic Pontine Glioma

DIPG, also referred to as pontine glioma, is a brainstem tumor that occurs almost exclusively in children under age 10. It affects several hundred children a year in the United States, but it's considered too rare for major research funding, so the prognosis has not improved in decades.

The Children's Brain Tumor Project at Weill Cornell Medicine Pediatric Brain and Spine Center has made DIPG research a priority by launching an innovative clinical trial testing convection-enhanced delivery (CED) of a therapeutic drug. The project is funded almost entirely by the families and communities of children diagnosed with the disease, who understand how critical it is to find answers. This site contains a wealth of information about DIPG, the clinical trial, and the Children's Brain Tumor Project.

Clinical Trial Update 2021
Dr. Souweidane presented an update on the trial at ASCO 2021. Although this Phase 1 trial is testing safety only, the median overall survival of all 46 patients in the study increased by three to four months as compared to the historical control group. The study will continue dose escalation for both infused volume and dose. "The results pave the way for our multicenter phase 2 study in DIPG later this year, where we expect to give up to three repeated doses of omburtamab,” stated Thomas Gad, founder, Chair and President of Y-mAbs, maker of the drug used in the trial. See press release from Y-mAbs Therapeutics.

NEWS:

Dr. Souweidane Presents DIPG Trial Update at ASCO 2019

Dr. Souweidane's Phase 1 Clinical Trial Findings Published in Lancet Oncology

Dr. Souweidane Presents Clinical Trial Results at ASCO 2017

Clinical Trial Update as of July 2017: We are currently recruiting additional patients on the Phase 1 study with further dose escalation. (Call 212-639-2336 for enrollment information.) Our concept for a multicenter study through the PBTC was recently approved by CTEP. This is a feasibility study. We are also submitting a Phase 1 study between MSKCC and UCSF for a different drug (Panobinostat) using CED in a similar fashion to what we have been doing. 

Dr. Souweidane's DIPG Clinical Trial

Published articles:
Advances in Molecular Imaging of Locally Delivered Targeted Therapeutics for Central Nervous System Tumors
Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells
A novel magnetic resonance imaging segmentation technique for determining diffuse intrinsic pontine glioma tumor volume

About DIPG
Basics of the tumor, how it progresses, and how it's treated

FAQs About DIPG
Answers to frequently asked questions about pontine glioma

Dr. Souweidane Extends His Clinical Trial for DIPG
A novel approach testing the safety of a new way to deliver tumor-fighting drugs

Dr. Souweidane's Blog Post: A New Beginning
Dr. Souweidane reflects on progress that's been made, and where we go from here

The Children's Brain Tumor Project
All about the research that's "powered by families"

More About DIPG
News, updates, and information about pontine gliomas and the search for a cure

Patient Stories:
Caitlin Downing
Cristian Rivera

 

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