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A Phase 2/3 Randomized, Open-Label Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma

This is a multicenter, randomized, open-label study of Toca 511 and Toca FC versus standard of care (SOC) in subjects undergoing resection for first or second recurrence (including this recurrence) of glioblastoma or anaplastic astrocytoma. Subjects will be randomized at the time of surgery in a 1:1 ratio to receive either Toca 511 and Toca FC or control; Investigator's choice of either single agent chemotherapy (lomustine or temozolomide) or bevacizumab.

A Prospective, Multi-center Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed GBM

This randomized controlled clinical trial sets to compare treatment using a new experimental device, the NovoTTF-100A, together with maintenance Temozolomide, to maintenance Temozolomide alone. Contact Dr. Susan Pannullo: 212-746-2438

Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy

This study tests an innovative convection-enhanced delivery (CED) technique that places a radioactive therapeutic agent (124I-8H9) at the site of the tumor using a surgically placed cannula.

Cordis Enterprise Vascular Reconstruction Device and Delivery System

The Cordis ENTERPRISE Vascular Reconstruction Device and Delivery System is authorized by federal law as a Humanitarian Use Device (a designation for devices that will be used to treat fewer than 4,000 people a year) for use with embolic coils for the treatment of wide-necked, intracranial aneurysms.

CREST (Carotid Revascularization Endarterectomy vs. Stenting) Trial

CREST is a prospective, multi-centered, NIH-funded trial to compare the results of treating carotid stenosis with either carotid endarterectomy or carotid stenting.

Deep Brain Stimulation for Treatment of Medically Refractory Cocaine Addiction

Addictive disorders are prevalent ailments that incur very high personal and social costs. In particular, cocaine addiction results in significant and permanent systemic changes to a patient, in addition to reducing personal and social productivity. While current therapies for cocaine addiction include psychosocial community reinforcement approaches, "vouchers" for abstinence, individual counseling, and pharmacologic treatment, there is a need for new tools for patients who relapse despite these conventional methods.

Gene Therapy for Batten Disease

Drs. Mark Souweidane and Michael Kaplitt are testing a new surgical procedure for Batten disease, or Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL), a rare, genetic, degenerative neurological disorder that usually becomes fatal in children by the age of 8 to 12.

Intraoperative Optical Mapping of Human Epileptiform and Functional Cortex

The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging

Medtronic Deep Brain Stimulation (DBS) Therapy for Dystonia

Medtronic Deep Brain Stimulation (DBS) Therapy for Dystonia is used to manage the symptoms of dystonia. It has been designated a Humanitarian Use Device (HUD) by the FDA and has been approved by the FDA under the Humanitarian Device Exemption (HDE) to aid in the management of certain types of chronic, intractable (drug refractory) dystonia. Brain stimulation involves the use of an implanted lead or leads to deliver electrical stimulation to parts of the brain to help control movement. Stimulation of these areas enables the brain circuits that control movement to function better.

MicroVention Low-Profile Visualized Intraluminal Support LVIS or LVIS Jr. Humanitarian Use Device (LVIS HUD)

The LVIS HUD is a stent (a small metallic mesh tube) that will be placed across the neck of the aneurysm; it is intended to remodel the blood vessel as well as provide support for the coils that will be placed inside the aneurysm. The purpose of the coils is to facilitate aneurysm occlusion by blocking blood flow into the aneurysm. The purpose of the treatment is to close off the aneurysm neck and lower the chance of aneurysm rupture.

Phase I/II Trial Of Super-Selective Intraarterial Infusion Of Erbitux (Cetuximab) And Avastin (Bevacizumab) For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age

It is unknown if currently used intravenous (IV) therapies even cross the blood brain barrier (BBB). We have shown in previous phase I trials that a single Superselective Intra-arterial Cerebral Infusion (SIACI) of Cetuximab and/or Bevacizumab is safe for the treatment of recurrent glioblastoma multiforme (GBM) in adults, and we are currently evaluating the efficacy of this treatment.

Phase II, Randomized, Double Blind, Placebo Controlled Study Evaluating the Treatment of Degenerative Lumbar Disc with Allogeneic Cultured Chondrocytes (NuQu)

The objective of this Phase II study is to provide rigorous focus on the safety evaluation of NuQu, and to gather data regarding the efficacy of NuQu as compared to placebo control. The Investigational material (NuQu) consists of culture-expanded, human, juvenile chondrocytes provided in a cryopreservation solution.

Prospective Quality of Life in Patients with Colloid Cysts of the Third Ventricle

This study sets out to assess the neuropsychological status and quality of life of patients who present with a colloid cyst of the third ventricle.

Contact Dr. Souweidane: 212-746-2363

Reclaim™ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (Humanitarian Use Device)

To provide deep brain stimulation therapy to alter pathological functioning of circuitry involved in causing medically-resistant obsessive-compulsive disorder.