Intra-Arterial Administration of Protein-Bound Paclitaxel (Abraxane) as a Radiosensitizer for Spinal and Paraspinal Metastatic Disease Refractory to Radiation Therapy

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Spinal metastatic disease is usually treated with radiation therapy and/or surgery. Certain spinal tumors do not respond well to radiation therapy alone and will recur after radiation therapy. This study aims to evaluate whether a new minimally invasive technique called spinal intra-arterial administration of protein-bound Paclitaxel (ABRAXANE) prior to radiation therapy is feasible and safe and to determine the dosage in patients who have already received radiation therapy but whose tumor recurs.

We hope that this new treatment will be proven useful by enhancing the therapeutic effect of radiation, preventing tumor progression and a serious neurological condition called cord compression.

Contact Dr. Athos Patsalides: 212-746-2821