Clinical Trials and Research Studies

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The Weill Cornell Brain and Spine Center is a national leader in clinical trials and research studies for neurosurgical conditions. These initiatives help achieve our mission of bringing our patients groundbreaking approaches to improving their diagnosis and treatment. 

Note: Clinical Trials (listed below) enroll patients in controlled tests of treatment options. Research Studies collect data about patients, treatments, and outcomes to help guide future treatment decisions. (See list of Research Studies)

Clinical trials are currently enrolling for:

Brain Tumors | Cerebrovascular Disorders | Epilepsy
Pediatric Neurosurgery | Movement Disorders
Pseudotumor Cerebri | Spine Conditions

Or review the complete list of our exciting clinical trials and studies (below).

 

A Phase 2/3 Randomized, Open-Label Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma

This is a multicenter, randomized, open-label study of Toca 511 and Toca FC versus standard of care (SOC) in subjects undergoing resection for first or second recurrence (including this recurrence) of glioblastoma or anaplastic astrocytoma. Subjects will be randomized at the time of surgery in a 1:1 ratio to receive either Toca 511 and Toca FC or control; Investigator's choice of either single agent chemotherapy (lomustine or temozolomide) or bevacizumab.

A Single-blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair

This clinical study is a non-inferiority study designed to evaluate the safety and efficacy of EVICEL® for use as an adjunct to sutured dural repair in cranial surgery as compared to DuraSeal Dural Sealant System. The study will assess both achievement of intra-operative watertight closure of the dural suture line and the occurrence of post-operative CSF leaks.

CAPTIVE

CAPTIVE: A Phase II, Multi-center, Open-label Study of a Conditionally Replicative Adenovirus (DNX-2401) with Pembrolizumab (KEYTRUDA) for Recurrent Glioblastoma or Gliosarcoma

Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy

This study tests an innovative convection-enhanced delivery (CED) technique that places a radioactive therapeutic agent (124I-8H9) at the site of the tumor using a surgically placed cannula.

Cordis Enterprise Vascular Reconstruction Device and Delivery System

The Cordis ENTERPRISE Vascular Reconstruction Device and Delivery System is authorized by federal law as a Humanitarian Use Device (a designation for devices that will be used to treat fewer than 4,000 people a year) for use with embolic coils for the treatment of wide-necked, intracranial aneurysms.

Deep Brain Stimulation for Treatment of Medically Refractory Cocaine Addiction

Addictive disorders are prevalent ailments that incur very high personal and social costs. In particular, cocaine addiction results in significant and permanent systemic changes to a patient, in addition to reducing personal and social productivity. While current therapies for cocaine addiction include psychosocial community reinforcement approaches, "vouchers" for abstinence, individual counseling, and pharmacologic treatment, there is a need for new tools for patients who relapse despite these conventional methods.

Intra-Arterial Administration of Protein-Bound Paclitaxel (Abraxane) as a Radiosensitizer for Spinal and Paraspinal Metastatic Disease Refractory to Radiation Therapy

To determine safety and feasibility of intra-arterial administration of protein-bond paciltaxel (Abraxane) in patients with spinal/paraspinal malignancies requiring initial or repeat radiation therapy.

Intra-arterial Chemotherapy for Spinal Metastases (SIAC)

Dr. Athos Patsalides

This phase I clinical research trial will test the hypothesis that a new minimally invasive treatment called spinal intra-arterial chemotherapy (SIAC) can be safely applied in patients with spinal metastatic disease.

Intraoperative Optical Mapping of Human Epileptiform and Functional Cortex

The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging

Medtronic Deep Brain Stimulation (DBS) Therapy for Dystonia

Medtronic Deep Brain Stimulation (DBS) Therapy for Dystonia is used to manage the symptoms of dystonia. It has been designated a Humanitarian Use Device (HUD) by the FDA and has been approved by the FDA under the Humanitarian Device Exemption (HDE) to aid in the management of certain types of chronic, intractable (drug refractory) dystonia. Brain stimulation involves the use of an implanted lead or leads to deliver electrical stimulation to parts of the brain to help control movement. Stimulation of these areas enables the brain circuits that control movement to function better.

MicroVention Low-Profile Visualized Intraluminal Support LVIS or LVIS Jr. Humanitarian Use Device (LVIS HUD)

The LVIS HUD is a stent (a small metallic mesh tube) that will be placed across the neck of the aneurysm; it is intended to remodel the blood vessel as well as provide support for the coils that will be placed inside the aneurysm. The purpose of the coils is to facilitate aneurysm occlusion by blocking blood flow into the aneurysm. The purpose of the treatment is to close off the aneurysm neck and lower the chance of aneurysm rupture.

Onyx Liquid Embolic System Onyx HD-500 (Humanitarian Use Device)

In this study, we plan to treat difficult aneurysms by embolization with Onyx, which is a liquid material that is delivered inside the aneurysm through the microcatheter instead of the coils.

Phase I/II Trial Of Super-Selective Intraarterial Infusion Of Erbitux (Cetuximab) And Avastin (Bevacizumab) For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age

It is unknown if currently used intravenous (IV) therapies even cross the blood brain barrier (BBB). We have shown in previous phase I trials that a single Superselective Intra-arterial Cerebral Infusion (SIACI) of Cetuximab and/or Bevacizumab is safe for the treatment of recurrent glioblastoma multiforme (GBM) in adults, and we are currently evaluating the efficacy of this treatment.

Reclaim™ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (Humanitarian Use Device)

To provide deep brain stimulation therapy to alter pathological functioning of circuitry involved in causing medically-resistant obsessive-compulsive disorder.

Selective Intra-Arterial Chemotherapy in the Treatment Strategy of Metastatic Spinal Disease

This is a preliminary study investigating the feasibility and safety of intra-arterial injection of chemotherapy to decrease epidural disease caused by metastatic spinal melanoma prior to radiotherapy.

Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy

The thalamus makes electrical connections with many parts of the brain, and stimulation there may oppose a patient's epilepsy and reduce seizures.

STING (Study of Immunotherapy in Newly Diagnosed Glioblastoma): A Phase III randomized double-blind, controlled study of ICT-107 with maintenance temozolomide (TMZ) in newly diagnosed glioblastoma following resection and concomitant TMZ chemoradiotherapy

Glioblastoma multiforme (GBM) is the most common and fast growing type of brain tumor. The study will compare overall survival and progression-free survival in patients when treated with the ICT-107 vaccine compared to the control.

Contact Dr. Pannullo: 212-746-2438

Topical Vancomycin for Craniotomies

This study has been designed as a single-blinded, multi-center, randomized clinical trial at New York Presbyterian Hospital Columbia and New York Presbyterian Hospital Cornell. The study population includes all adult craniotomies performed at each institution over a 4 year and 9 month time period. The treatment variable is the application of topical vancomycin to the surgical site. If a craniotomy is performed, a paste made from vancomycin powder and sterile solution will be applied to the edges and outer surface of the craniotomy.

Venous Sinus Stenting in Patients with Refractory Idiopathic Intracranial Hypertension (IIH)

There are many patients with Idiopathic Intracranial Hypertension (IIH), also known as pseudotumor cerebri, who do not respond to available treatments or experience medication-related side effects that affect their quality of life. A new clinical trial aims to evaluate the safety and efficacy of venous sinus stenting in patients with refractory IIH and significant venous sinus stenosis.

Wide-Neck Aneurysms: The Neuroform Stent and the Enterprise Stent System

These two stents are small metallic mesh tubes designed to keep the coils in the aneurysm sac, in intracranial wide-neck aneurysms.

Wingspan Stent System PTA Balloon Catheter (Humanitarian Use Device)

The Wingspan Stent System with the gateway tm PTA balloon catheter is intended for use in improving cerebral artery lumen diameter in patients with intracranial atherosclerotic disease refractory to medical therapy, in intracranial arteries with greater than or equal to 50% stenosis.