Current Research Studies

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Active Research Studies:

 

Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy

Over a 36-month period, we will participate in a multicenter pilot study headed by the University of Colorado-Anschutz Medical Center (UC-AMC) that includes member institutions of POETIC as well as

Children’s Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Specimens

Patients treated at Weill Cornell Medicine are eligible for this study, in which tumor tissue specimens and blood will be collected and stored in an effort to help scientists understand the biology of pediatric brain tumors. Contact Dr. Mark M. Souweidane: 212-746-2363

Cognitive and Sensorimotor Event-Related Potentials Recorded With Subdural and Depth Electrodes

This study examines the neural mechanisms involved in basic perceptual and cognitive processes in the visual, auditory and somatosensory domains. Intra-cranial electrophysiological recording will be taken from patients undergoing subdural grid studies prior to surgical treatment for medically refractory partial epilepsy. Contact Dr. Theodore Schwartz: 212-746-5620

CT angiography of the enucleated eye in children with bilateral retinoblastoma

In patients currently undergoing ophthalmic artery chemosurgery, we plan to use CT angiography in the contralateral ophthalmic artery to describe changes in orbital vasculature following enucleation. Contact Dr. Gobin: 212-746-4998

Diagnosis and Prevention of Low-Grade Brain Tumor Malignant Transformation by Detection and Monitoring of Circulating Endothelial Progenitor Cells

Recent research suggests that a key factor in glioma progression is the growth of new blood vessels via stem cells from bone marrow.

Endoscopic Skull Base Surgery

This study involves a retrospective chart review and outpatient survey of patients who have already undergone endoscopic skull base surgery at our institution by the PI (Dr. Theodore Schwartz).

Harvesting of Excess Bone Marrow for the Collection of Human Mesenchymal Stem Cells

The purpose of this project is to use excess bone marrow taken during spinal fusion surgeries to isolate human mesenchymal stem cells for use in tissue-engineered constructs.

Intra-operative use of indigo carmine dye for the delineation of ill-defined tumor borders using stereotactic injection

Low grade gliomas are brain tumors with usually poorly defined borders between tumor and normal brain. This characteristic of low grade gliomas makes the gross total resection of the tumor extremely difficult. Nevertheless, several studies have demonstrated that the risk of recurrence and progression into a more malignant tumor can be decreased with a more aggressive surgical resection.

Long-term cognitive and quality of life effects of pediatric brain tumor resections

To assess the capacity for long-term hemispheric reorganization of language via neuropsychological measures of language function in pediatric patients one to ten years after left hemispheric tumor resection.

Molecular genetics of gliomatosis cerebri

The purpose of this study is to collect previously obtained brain cancer tissue samples to perform molecular characterization.

Contact Dr. Greenfield: 212-746-2363

Neurological Surgery Patient Registry

The primary purpose and design of this registry is to track quality of surgical care for the most common neurosurgical procedures, as well as provide an immediate infrastructure for analyzing and r

Non-operative management of suspected eosinophilic granuloma of skull

The purpose of this study is to evaluate the outcomes of children with probable isolated calvarial eosinophilic granuloma (EG) managed with an initial protocol of observation only.

Registry of Retinoblastoma Patients Receiving Intra-Arterial Chemotherapy

Dr. Y. Pierre Gobin of Weill Cornell and Dr. David Abramson of Memorial Sloan-Kettering are conducting a study to track the use of intra-arterial chemotherapy for retinoblastoma (a cancer of the eye in young children). This procedure saves approximately 80 percent of eyes in children who are referred immediately with no prior treatment, and 50 percent of eyes in children treated after having failed prior treatments at other institutions.

Research for Precision Medicine in Pediatric Oncology

Sequencing of advanced and metastatic tumors has the potential to contribute substantially to the scientific community.

Role of bone marrow-derived endothelial cells in low grade brain tumors

Much research has focused on malignant glioblastoma in the attempt to discover potential treatments, however little or no studies exist that have focused on the behavior of low-grade gliomas before

Using Genomic Analysis to Guide Individualized Treatment in Glioblastoma Multiforme (GBM)

Currently, there is no effective treatment for glioblastoma multiforme (GBM).

Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions

The purpose of this study is to use Fluorescein Sodium, which is a type of dye, to help the surgeons get a better picture of brain lesions in the operating room during surgery.