Our Surgical Programs
Biomarker based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.

Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a universally poor prognosis.
Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells.

While the tumor microenvironment has been known to play an integral role in tumor progression, the function of non-resident bone marrow-derived cells (BMDCs) remains to be determined in neurologica
Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche.

Glioblastoma multiforme (GBM) contains a subpopulation of cancer stem-like cells (CSCs) believed to underlie tumorigenesis and therapeutic resistance.
Stereotactic Radiosurgery Plays a Critical Role in Enhancing Long-term Survival in a Patient with Pancreatic Cancer Metastatic to the Brain

Rajappa P, Margetis K, Wernicke G, Ginter P, Cope W, Sherr DL, Lavi E, Fine RL, Schwartz TH, Bruckner H, Pannullo SC.
Endoscopic endonasal transclival approach to a ventral pontine pediatric ependymoma

Endoscopic endonasal transclival approach to a ventral pontine pediatric ependymoma. Rajappa P, Margetis K, Sigounas D, Anand V, Schwartz TH, Greenfield JP. J Neurosurg Pediatr. 2013 Aug 30.
Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: from bedside to bench

Bevacizumab (BV), a humanized monocolonal antibody directed against vascular endothelial growth factor (VEGF), is a standard intravenous (IV) treatment for recurrent glioblastoma multiforme (GBM),