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Glioblastoma Multiforme (GBM)

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Symptoms of Glioblastoma Multiforme

As with many brain tumors, the most common initial symptom of glioblastoma multiforme is headache. Since the symptoms are often caused by the pressure of a tumor against adjacent brain structures, the symptoms may vary depending on where in the brain or spine the tumor is located. Symptoms of GBM include:

  • Weakness or numbness in the limbs
  • Nausea and vomiting (especially on awakening)
  • Cognitive impairment, memory loss, and inability to concentrate
  • Seizures
  • Personality and mood changes
  • Visual changes

Most people with headaches and nausea do not have brain tumors, of course, but anyone with neurological symptoms like those listed above should be evaluated by a physician. Suspected or confirmed brain tumors should be referred to a neurosurgeon for evaluation (see Doctors Who Treat Glioblastoma Multiforme).

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Reviewed by: Rohan Ramakrishna, M.D.
Last reviewed/last updated: January 2015