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Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells.

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Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells.

While the tumor microenvironment has been known to play an integral role in tumor progression, the function of non-resident bone marrow-derived cells (BMDCs) remains to be determined in neurological tumors. Here we identified the contribution of BMDC recruitment in mediating malignant transformation from low- to high-grade gliomas.

Publication Name: 
Clinical Cancer Research
Authors: 
Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse JT, Pisapia DJ, Chan TA, Lyden D, Bromberg J, Greenfield JP

 

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