Diagnosing and Treating Acromegaly

Acromegaly can be difficult to diagnose, since patients may experience seemingly unrelated symptoms. (Widening feet, skin tags, vision problems, and changes in libido are just a few of the varied symptoms of acromegaly.) An individual may have sought treatment for these symptoms individually – from a primary care doctor, an eye doctor, a dermatologist, or other specialist. Since a patient may not mention the full list of symptoms to the specialists, neither the patient nor the doctors may recognize the connection immediately.

When acromegaly is suspected, the patient should be given blood tests to measure levels of growth hormone (GH) and insulin-like growth factor I (IGF-I). Based on the results, dynamic testing (GH suppression test) may be needed. If the test results indicate acromegaly, the patient will then be sent for imaging tests to look for a pituitary tumor.

Magnetic resonance imaging (MRI) scans produce detailed images of the brain and allow doctors to detect the presence of a tumor. The test is noninvasive, but it requires time in a scanner to produce tiny slices of images that are then combined into three-dimensional pictures. Sometimes the patient will need a special contrast agent in advance to increase the visibility of any abnormality found.

Treatment Options
Acromegaly is most often treated surgically, by removing the pituitary tumor causing the overproduction of growth hormone. At times medical treatment can be recommended for a short period of time prior to surgery to improve potential anesthesia complications or surgical outcomes. (See Surgery for a Pituitary Tumor.) In cases where surgery is not recommended pituitary tumors may be treated with medications to suppress GH production or block its effects at the receptor level. If the disease persists, long-term medications or radiation could be used.

Pituitary tumors are complex lesions that should be treated at major medical centers, by a team experienced in the diagnosis and treatment of tumors affecting the hormones. For each patient the treatment is highly individualized considering all available surgical, medical and radiation tools as well as clinical trials.

Weill Cornell Brain and Spine Center is fortunate to be home to an internationally recognized surgical team with advanced skills in minimally invasive procedures to remove pituitary tumors. Neurosurgeon Theodore Schwartz, MD, routinely uses endonasal (through the nose) approaches to removing pituitary tumors, with no head or facial scarring. (See video of endonasal surgery technique.) The team has operated successfully on tumors that other surgeons have deemed impossible to remove. (See video of patient who had a giant tumor removed endonasally.) Dr. Dobri is well versed in all available medications for acromegaly and has taken care of many patients with complex disease that requires combination medical therapy.

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Our Care Team

  • Vice Chair for Clinical Research
  • David and Ursel Barnes Professor in Minimally Invasive Surgery
  • Professor of Neurosurgery, Neurology, and Otolaryngology
  • Director, Center for Epilepsy and Pituitary Surgery
  • Co-Director, Surgical Neuro-oncology
Phone: 212-746-5620
  • Assistant Professor of Neurological Surgery
  • Leon Levy Research Fellow
  • Feil Family Brain and Mind Research Institute
Phone: 646-962-3389
  • Assistant Professor of Neuroendocrinology in Neurological Surgery, Weill Cornell Medicine
Phone: 646-962-3556
  • Director, Neurosurgical Radiosurgery
  • Associate Professor of Clinical Neurological Surgery
  • Robert G. Schwager, MD ’67 Education Scholar, Cornell University
Phone: 212-746-2438
  • Chief of Neurological Surgery, NewYork-Presbyterian Brooklyn Methodist
  • Alvina and Willis Murphy Associate Professor, Neurological Surgery
  • Director, Brain Metastases Program
  • Co-director, William Rhodes and Louise Tilzer-Rhodes Center for Glioblastoma
Phone: 212-746-1996

Reviewed by: Georgiana Dobri, M.D.
Last reviewed/last updated: December 2020

Weill Cornell Medicine Brain & Spine Center 525 East 68 Street, Box 99 New York, NY 10065 Phone: 866-426-7787